Review
Nature Reviews Molecular Cell Biology 5, 647-657 (August 2004) | doi:10.1038/nrm1436
Foot and mouth: podosomes, invadopodia and circular dorsal ruffles
Roberto Buccione1, James D. Orth2 & Mark A. McNiven2 About the authors
Abstract
The plasma membrane of many motile cells undergoes highly regulated protrusions and invaginations that support the formation of podosomes, invadopodia and circular dorsal ruffles. Although they are similar in appearance and in their formation — which is mediated by a highly conserved actin–membrane apparatus — these transient surface membrane distortions are distinct. Their function is to help the cell as it migrates, attaches and invades.
- View At a Glance
Author affiliations
- Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, Santa Maria Imbaro (Chieti), Italy.
- Department of Biochemistry and Molecular Biology, Center for Basic Research in Digestive Diseases, Mayo Clinic, Rochester, Minnesota, USA.
Correspondence to: Mark A. McNiven2 Email: mcniven.mark@mayo.edu
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Foot in mouth: do focal adhesions disassemble by endocytosis?Nature Cell Biology News and Views (01 Jun 2005)
Extending the court for cortactin: from the cortex to the GolgiNature Cell Biology News and Views (01 May 2005)
See all 4 matches for News And ViewsRESEARCH
WAVE2 deficiency reveals distinct roles in embryogenesis and Rac-mediated actin-based motilityThe EMBO Journal Article (15 Jul 2003)
See all 46 matches for Research
