Review
Nature Reviews Molecular Cell Biology 5, 647-657 (August 2004) | doi:10.1038/nrm1436
Foot and mouth: podosomes, invadopodia and circular dorsal ruffles
Roberto Buccione1, James D. Orth2 & Mark A. McNiven2 About the authors
Abstract
The plasma membrane of many motile cells undergoes highly regulated protrusions and invaginations that support the formation of podosomes, invadopodia and circular dorsal ruffles. Although they are similar in appearance and in their formation — which is mediated by a highly conserved actin–membrane apparatus — these transient surface membrane distortions are distinct. Their function is to help the cell as it migrates, attaches and invades.
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Author affiliations
- Department of Cell Biology and Oncology, Consorzio Mario Negri Sud, Santa Maria Imbaro (Chieti), Italy.
- Department of Biochemistry and Molecular Biology, Center for Basic Research in Digestive Diseases, Mayo Clinic, Rochester, Minnesota, USA.
Correspondence to: Mark A. McNiven2 Email: mcniven.mark@mayo.edu
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