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Review
Nature Reviews Molecular Cell Biology 5, 531–541 (1 July 2004) | doi:10.1038/nrm1427
Insights into morphogenesis from a simple developmental system
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Abstract
We are only starting to understand the molecular mechanisms that underlie cell and tissue movements during morphogenesis in metazoans. Dictyostelium discoideum provides a valuable model system for understanding these events — as it has for chemotaxis — despite the many differences that exist between this social amoeba and more complex organisms. Genetic and genomic studies, combined with real-time imaging, have identified key pathways that regulate morphogenesis in D. discoideum, and which are likely to have similar roles in metazoans.
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