Review
Nature Reviews Molecular Cell Biology 5, 542-553 (July 2004) | doi:10.1038/nrm1425
Plakins: Goliaths that link cell junctions and the cytoskeleton
Julius J. Jefferson1, Conrad L. Leung1 & Ronald K. H. Liem1 About the authors
Abstract
Plakins comprise a family of proteins that crosslink cytoskeletal filaments and attach them to membrane-associated complexes at cell junctions. They were originally found associated with intermediate filaments and were believed to function primarily in maintaining epithelial tissue integrity. However, new plakins with unique isoforms that are enormous in size have been identified in the past few years. These new plakins have highlighted further functions in all the cytoskeletal networks, as well as in non-epithelial cells.
- View At a Glance
Author affiliations
- Departments of Pathology and Anatomy & Cell Biology, Columbia University College of Physicians & Surgeons, 630 West 168th Street, New York 10032, USA.
Correspondence to: Ronald K. H. Liem1 Email: rkl2@columbia.edu
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
A new fold on an old story: attachment of intermediate filaments to desmosomesNature Structural Biology News and Views (01 Aug 2002)
Weaving a tangled web: the interconnected cytoskeletonNature Cell Biology News and Views (01 Sep 1999)
See all 4 matches for News And ViewsRESEARCH
Crystal structure of human osteoclast cathepsin K complex with E-64Nature Structural Biology Correspondence (01 Feb 1997)
Association of Plectin with Z-Discs Is a Prerequisite for the Formation of the Intermyofibrillar Desmin CytoskeletonLaboratory Investigation Article Response
See all 25 matches for Research
