Abstract

Plakins comprise a family of proteins that crosslink cytoskeletal filaments and attach them to membrane-associated complexes at cell junctions. They were originally found associated with intermediate filaments and were believed to function primarily in maintaining epithelial tissue integrity. However, new plakins with unique isoforms that are enormous in size have been identified in the past few years. These new plakins have highlighted further functions in all the cytoskeletal networks, as well as in non-epithelial cells.

Author affiliations

1. Departments of Pathology and Anatomy & Cell Biology, Columbia University College of Physicians & Surgeons, 630 West 168^th Street, New York 10032, USA.

Correspondence to: Ronald K. H. Liem¹ Email: rkl2@columbia.edu

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