Abstract

Lysosomal storage disorders, of which more than 40 are known, are caused by the defective activity of lysosomal proteins, which results in the intra-lysosomal accumulation of undegraded metabolites. Despite years of study of the genetic and molecular bases of lysosomal storage disorders, little is known about the events that lead from this intra-lysosomal accumulation to pathology. Here, we summarize the biochemistry of lysosomal storage disorders. We then discuss downstream cellular pathways that are potentially affected in these disorders and that might help us to delineate their pathological mechanisms.

Author affiliations

1. Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel.
   Email: tony.futerman@weizmann.ac.il
2. Department of Membrane Enzymology, Institute of Biomembranes, Utrecht University, 3584 CH Utrecht, The Netherlands.
   Email: g.vanmeer@chem.uu.nl

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