Abstract

Transcription is a stepwise process that involves many specialized proteins and protein complexes, all of which must work together to express a given gene in a spatially and temporally regulated manner. An integral step in this regulatory process is carried out by large, multisubunit co-activator complexes, which have diverse roles in transcriptional control. Their diversity and large size allows for many potential regulatory inputs, but how is the versatility and specificity of these co-activator complexes determined?

Author affiliations

1. Dylan J. Taatjes is at the University of Colorado, Department of Chemistry and Biochemistry, Campus Box 215, Boulder, Colorado 80309, USA.
2. Michael T. Marr and Robert Tjian are at the Howard Hughes Medical Institute, Department of Molecular and Cell Biology, 401 Barker Hall, University of California, Berkeley, California 94720, USA.

Correspondence to: Robert Tjian² Email: jmlim@uclink.berkeley.edu

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