Review
Nature Reviews Molecular Cell Biology 5, 392-401 (May 2004) | doi:10.1038/nrm1368
Shaping the nuclear action of NF-
B
Lin-Feng Chen1 & Warner C. Greene1,2,3 About the authors
Abstract
The NF-
B/REL family of transcription factors pivotally control the inflammatory and immune responses, as well as other genetic programmes that are central to cell growth and survival. The cytoplasmic regulation of NF-B is well characterized and, recently, significant progress has been made in understanding how its nuclear action is regulated. Post-translational modification of the NF-B subunits as well as histones surrounding the NF-B target genes has a key role in this regulation. Here, we review the important advances that constitute this new and exciting chapter in NF-B biology.
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Author affiliations
- Gladstone Institute of Virology and Immunology, University of California, San Francisco, California 94141, USA.
- Department of Medicine, University of California, San Francisco, California 94141, USA.
- Department of Microbiology and Immunology, University of California, San Francisco, California 94141, USA.
Correspondence to: Warner C. Greene1,2,3 Email: wgreene@gladstone.ucsf.edu
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