Review
Nature Reviews Molecular Cell Biology 5, 343-354 (May 2004) | doi:10.1038/nrm1366
Oxygen sensing by HIF hydroxylases
Christopher J. Schofield1 & Peter J. Ratcliffe2 About the authors
Abstract
The transcription factor HIF (hypoxia-inducible factor) has a central role in oxygen homeostasis in animals ranging from nematode worms to man. Recent studies have shown that this factor is regulated by an unprecedented signalling mechanism that involves post-translational hydroxylation. This hydroxylation is catalysed by a set of non-haem, Fe2+-dependent enzymes that belong to the 2-oxoglutarate-dependent-oxygenase superfamily. The absolute requirement of these enzymes for molecular oxygen has provided new insights into the way cells sense oxygen.
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Author affiliations
- The Oxford Centre for Molecular Sciences and The Dyson Perrins Laboratory, Department of Chemistry, South Parks Road, Oxford OX1 3QY, UK.
- The Henry Wellcome Building of Genomic Medicine, Roosevelt Drive, Oxford OX3 7BN, UK.
Correspondence to: Peter J. Ratcliffe2 Email: pjr@well.ox.ac.uk
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