Abstract

Recent progress has been made in our understanding of the molecular mechanisms that regulate the biogenesis of multivesicular transport intermediates in the degradation pathway that leads to lysosomes. Here, we discuss recent work that uncovers some of the mechanisms that cause both membrane invagination within these newly forming intermediates and the detachment of these intermediates from early endosomal membranes.

Author affiliations

1. Jean Gruenberg is in the Department of Biochemistry, University of Geneva, 30 quai Ernest Ansermet, 1211-Geneva-4, Switzerland.
   Email: jean.gruenberg@biochem.unige.ch
2. Harald Stenmark is in Department of Biochemistry, Institute for Cancer Research, Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway.
   Email: h.a.stenmark@farmasi.uio.no

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