Abstract

Heterochromatin maintenance is crucial for the clonal inheritance of cell identity, to ensure the proper segregation of chromosomes and the regulation of gene expression. Although it is architecturally stable, heterochromatin has to be flexible to cope with disrupting events such as replication. Recent progress has shed light on the paradoxical properties of heterochromatin in the nucleus, and highlights the roles of heterochromatin protein-1 and, more unexpectedly, RNA molecules in heterochromatin maintenance.

Author affiliations

1. Unité Mixte de Reserche 218 Centre National de la Recherche Scientifique/Institut Curie-Section de Recherche, 26 rue d'Ulm, 75231 Paris Cedex 05, France.

Correspondence to: Geneviève Almouzni¹ Email: Genevieve.Almouzni@curie.fr

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