Review
Nature Reviews Molecular Cell Biology 5, 282-295 (April 2004) | doi:10.1038/nrm1354
Biology, structure and mechanism of P-type ATPases
Werner Kühlbrandt1 About the author
Abstract
P-type ATPases are ion pumps that carry out many fundamental processes in biology and medicine, ranging from the generation of membrane potential to muscle contraction and the removal of toxic ions from cells. Making use of the energy stored in ATP, they transport specific ions across the cell membrane against a concentration gradient. Recent X-ray structures and homology models of P-type pumps now provide a basis for understanding the molecular mechanism of ATP-driven ion transport.
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Author affiliations
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Max-Planck Institut für Biophysik, Marie-Curie-Stra
e 13–15, 60439 Frankfurt am Main, Germany.
Email: Werner.Kuehlbrandt@mpibp-frankfurt.mpg.de
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