Abstract

Viruses use a surprising diversity of approaches to hijack G-protein-coupled receptors and harness their activated intracellular signalling pathways. All of these approaches ultimately function to ensure viral replicative success and often contribute to their pathogenesis. Indeed, a single virus might deploy a repertoire of these strategies to regulate key intracellular survival, proliferative and chemotactic pathways. Understanding the contribution of these biochemical routes to viral pathogenesis might facilitate the development of effective target-specific therapeutic strategies against viral diseases.

Author affiliations

1. Cell Growth Regulation Section, Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, 30 Convent Drive, Building 30, Room 211, Bethesda, Maryland 20892-4330, USA.

Correspondence to: Silvia Montaner¹ Email: silvia.montaner@nih.gov

Correspondence to: J. Silvio Gutkind¹ Email: sg39v@nih.gov

MORE ARTICLES LIKE THIS

These links to content published by NPG are automatically generated.