Abstract

Multiprotein signalling networks create focal points of enzyme activity that disseminate the intracellular action of many hormones and neurotransmitters. Accordingly, the spatio-temporal activation of protein kinases and phosphatases is an important factor in controlling where and when phosphorylation events occur. Anchoring proteins provide a molecular framework that orients these enzymes towards selected substrates. A-kinase anchoring proteins (AKAPs) are signal-organizing molecules that compartmentalize various enzymes that are regulated by second messengers.

Author affiliations

1. Howard Hughes Medical Institute/Vollum Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Road, L-474, Portland, Oregon 97239, USA.

Correspondence to: John D. Scott¹ Email: scott@ohsu.edu

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