Review
Nature Reviews Molecular Cell Biology 5, 792-804 (October 2004) | doi:10.1038/nrm1493
Checking on DNA damage in S phase
Jiri Bartek1, Claudia Lukas1 & Jiri Lukas1 About the authors
Abstract
The precise replication of the genome and the continuous surveillance of its integrity are essential for survival and the avoidance of various diseases. Cells respond to DNA damage by activating a complex network of the so-called checkpoint pathways to delay their cell-cycle progression and repair the defects. In this review we integrate findings on the emerging mechanisms of activation, the signalling pathways and the spatio-temporal organization of the intra-S-phase DNA-damage checkpoint and its impact on the cell-cycle machinery, and discuss its biological significance.
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Author affiliations
- Danish Cancer Society, Institute of Cancer Biology, Strandboulevarden 49, DK-2100 Copenhagen, Denmark.
Correspondence to: Jiri Bartek1 Email: bartek@biobase.dk
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