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Sorting out the nuclear envelope from the endoplasmic reticulum

Nature Reviews Molecular Cell Biology volume 5, pages 65–69 (2004)Cite this article

Abstract

Although the interphase nuclear envelope is continuous with the endoplasmic reticulum, it is distinct from the endoplasmic reticulum in both form and composition. In metazoans, the nuclear envelope breaks down during mitosis and is thought to be completely reabsorbed by the endoplasmic reticulum. How these near neighbours are sorted out at the end of mitosis is an interesting mystery.

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Figure 1: The nuclear envelope and inner-nuclear-membrane-protein sorting during interphase.
Figure 2: Steps involved in postmitotic nuclear-envelope formation in vitro.
Figure 3: A model for the segregation of nuclear-envelope-specific proteins from bulk endoplasmic reticulum in vivo.
Figure 4: RAB-dependent endosome membrane domains.

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Acknowledgements

I wish to thank P. Riedinger, M. Hetzer and M. Zerial for the figures, and J. Ellenberg, M. Knop, M. Hetzer and W. Antonin for critical comment on the manuscript.

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Authors and Affiliations

  1. the European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg, D-69117, Germany

    Iain W. Mattaj

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  1. Iain W. Mattaj
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DATABASES

Swiss-Prot

BAF

HP1

LAP2β

NPL4

NUP107

NUP160

p97

POM121

RAB4

RAB5

RAB11

SAR1

UFD1

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Mattaj, I. Sorting out the nuclear envelope from the endoplasmic reticulum. Nat Rev Mol Cell Biol 5, 65–69 (2004). https://doi.org/10.1038/nrm1263

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