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Review
Nature Reviews Molecular Cell Biology 4, 690–699 (1 September 2003) | doi:10.1038/nrm1200
Nuclear and unclear functions of SUMO
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Abstract
Post-translational modification by the ubiquitin-like SUMO protein is emerging as a defining feature of eukaryotic cells. Sumoylation has crucial roles in the regulatory challenges that face nucleate cells, including the control of nucleocytoplasmic signalling and transport and the faithful replication of a large and complex genome, as well as the regulation of gene expression.
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