Review

Nature Reviews Molecular Cell Biology 4, 690-699 (September 2003) | doi:10.1038/nrm1200

Nuclear and unclear functions of SUMO

Jacob-S. Seeler1 & Anne Dejean1  About the authors

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Post-translational modification by the ubiquitin-like SUMO protein is emerging as a defining feature of eukaryotic cells. Sumoylation has crucial roles in the regulatory challenges that face nucleate cells, including the control of nucleocytoplasmic signalling and transport and the faithful replication of a large and complex genome, as well as the regulation of gene expression.

Author affiliations

  1. Nuclear Organization and Oncogenesis Unit, INSERM U 579, Institut Pasteur, 28 rue du Dr. Roux, 75724 Paris Cedex 15, France.

Correspondence to: Anne Dejean1 Email: adejean@pasteur.fr

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