Review
Nature Reviews Molecular Cell Biology 4, 700-711 (September 2003) | doi:10.1038/nrm1199
Phosphatases in cell–matrix adhesion and migration
Melinda Larsen1, Michel L. Tremblay2 & Kenneth M. Yamada1 About the authors
Abstract
Many proteins that have been implicated in cell–matrix adhesion and cell migration are phosphorylated, which regulates their folding, enzymatic activities and protein–protein interactions. Although modulation of cell motility by kinases is well known, increasing evidence confirms that phosphatases are essential at each stage of the migration process. Phosphatases can control the formation and maintenance of the actin cytoskeleton, regulate small GTPase molecular switches, and modulate the dynamics of matrix–adhesion interaction, actin contraction, rear release and migratory directionality.
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Author affiliations
- Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Building 30/Room 421, 30 Convent Drive, MSC 4370, Bethesda, Maryland 20892-4370, USA.
- McGill Cancer Centre and Department of Biochemistry, McGill University, Montreal, Quebec, Canada H3G 1Y6.
Correspondence to: Melinda Larsen1 Email: mlarsen@mail.nih.gov
Correspondence to: Michel L. Tremblay2 Email: kyamada@mail.nih.gov
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