Review
Nature Reviews Molecular Cell Biology 4, 679-689 (September 2003) | doi:10.1038/nrm1198
Titin: properties and family relationships
Larissa Tskhovrebova1 & John Trinick1 About the authors
Abstract
In striated muscles, the rapid production of macroscopic levels of force and displacement stems directly from highly ordered and hierarchical protein organization, with the sarcomere as the elemental contractile unit. There is now a wealth of evidence indicating that the giant elastic protein titin has important roles in controlling the structure and extensibility of vertebrate muscle sarcomeres.
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Author affiliations
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Astbury Centre for Structural Molecular Biology, and School of Biomedical Sciences, University of Leeds, Leeds LS2 9JT, UK.
Email: L.Tskhovrebova@leeds.ac.uk
Email: J.Trinick@leeds.ac.uk
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