Review
Nature Reviews Molecular Cell Biology 4, 621-631 (August 2003) | doi:10.1038/nrm1176
A tale of two polymers: new insights into helical filaments
Edward H. Egelman1 About the author
Abstract
Many proteins function as helical polymers within the cell. Two intensively studied examples are eukaryotic actin and bacterial RecA, which belong to two different protein superfamilies. However, most other members of these superfamilies do not polymerize into helical filaments. General features of polymorphism, cooperativity and allostery that emerge from studies of eukaryotic actin and bacterial RecA raise more general issues about how conserved these filamentous structures have been during evolution.
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Author affiliations
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Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908-0733, USA.
Email: egelman@virginia.edu
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