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Review
Nature Reviews Molecular Cell Biology 4, 446–456 (1 June 2003) | doi:10.1038/nrm1128
ROCKs: multifunctional kinases in cell behaviour
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Abstract
ROCKs, or Rho kinases, are serine/threonine kinases that are involved in many aspects of cell motility, from smooth-muscle contraction to cell migration and neurite outgrowth. Recent experiments have defined new functions of ROCKs in cells, including centrosome positioning and cell-size regulation, which might contribute to various physiological and pathological states.
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