Review
Nature Reviews Molecular Cell Biology 4, 479-489 (June 2003) | doi:10.1038/nrm1130
Fibulins: a versatile family of extracellular matrix proteins
Rupert Timpl1, Takako Sasaki2, Günter Kostka2 & Mon-Li Chu3 About the authors
Abstract
Fibulins are a newly recognized family of extracellular matrix proteins. The five known members of the family share an elongated structure and many calcium-binding sites, owing to the presence of tandem arrays of epidermal growth factor-like domains. They have overlapping binding sites for several basement-membrane proteins, tropoelastin, fibrillin, fibronectin and proteoglycans, and they participate in diverse supramolecular structures. New insights into their biological roles are now emerging from studies of transgenic mice and of some inherited human diseases.
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Author affiliations
- Laboratory of Protein Chemistry, Max Planck Institute for Biochemistry, D-82152 Martinsried, Germany.
- Department of Molecular Medicine, Max Planck Institute for Biochemistry, D-82152 Martinsried, Germany.
- Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia 19107, USA.
Correspondence to: Rupert Timpl1 Email: timpl@biochem.mpg.de
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