Review
Nature Reviews Molecular Cell Biology 4, 446-456 (June 2003) | doi:10.1038/nrm1128
ROCKs: multifunctional kinases in cell behaviour
Kirsi Riento1 & Anne J. Ridley1,2 About the authors
Abstract
ROCKs, or Rho kinases, are serine/threonine kinases that are involved in many aspects of cell motility, from smooth-muscle contraction to cell migration and neurite outgrowth. Recent experiments have defined new functions of ROCKs in cells, including centrosome positioning and cell-size regulation, which might contribute to various physiological and pathological states.
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Author affiliations
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Ludwig Institute for Cancer Research, Royal Free and University College School of Medicine, 91 Riding House Street, London W1W 7BS, UK.
Email: kirsi@ludwig.ucl.ac.uk -
Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.
Email: anne@ludwig.ucl.ac.uk
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