Perspectives
Nature Reviews Molecular Cell Biology 4, 497-502 (June 2003) | doi:10.1038/nrm1126
Opinion: The present view of the mechanism of protein folding
Valerie Daggett1 & Alan Fersht2 About the authors
Abstract
We can track the positions and movements of all the atoms in small proteins as they fold and unfold by combining experimental studies with atomic-resolution molecular dynamics simulations. General principles as to how such complex architectures form so rapidly are now emerging from in-depth studies of a few proteins.
Author affiliations
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Valerie Daggett is at the Department of Medicinal Chemistry, Box 357610, University of Washington, Seattle, Washington 98195–7610, USA.
Email: daggett@u.washington.edu -
Alan Fersht is at the Department of Chemistry, Lensfield Road, Cambridge CB2 1EW, UK, and the MRC Centre for Protein Engineering, MRC Centre, Hills Road, Cambridge CB2 2QH, UK.
Email: arf25@cam.ac.uk
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