Perspectives
Nature Reviews Molecular Cell Biology 4, 491-497 (June 2003) | doi:10.1038/nrm1124
Opinion: When ubiquitin meets ubiquitin receptors: a signalling connection
Pier Paolo Di Fiore1,2, Simona Polo2 & Kay Hofmann3 About the authors
Abstract
Ubiquitylation is emerging as a versatile device for controlling cellular functions. Here, we propose that monoubiquitylation is rapidly induced by signalling events and allows the establishment of protein–protein interactions between monoubiquitylated proteins and partners that contain distinct ubiquitin-binding domains. We also put forward speculative models for the regulation of monoubiquitylation versus polyubiquitylation.
Author affiliations
- Pier Paolo Di Fiore and Simona Polo are at the Istituto Europeo di Oncologia, Via Ripamonti 435, 20141, Milan, Italy, and Istituto FIRC di Oncologia Molecolare, 20139, Milan, Italy.
- Pier Paolo Di Fiore is also at the University of Milan, 20122, Milan, Italy.
- Kay Hofmann is at MEMOREC Stoffel GmbH, Stoeckheimer Weg 1, D50829 Koeln, Germany.
Correspondence to: Pier Paolo Di Fiore1,2 Email: pdifiore@ieo.it
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