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When ubiquitin meets ubiquitin receptors: a signalling connection

Nature Reviews Molecular Cell Biology volume 4, pages 491–497 (2003)Cite this article

Abstract

Ubiquitylation is emerging as a versatile device for controlling cellular functions. Here, we propose that monoubiquitylation is rapidly induced by signalling events and allows the establishment of protein–protein interactions between monoubiquitylated proteins and partners that contain distinct ubiquitin-binding domains. We also put forward speculative models for the regulation of monoubiquitylation versus polyubiquitylation.

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Figure 1: Ubiquitin-receptor proteins.
Figure 2: Monoubiquitylation and signalling.
Figure 3: Models to explain UIM function in monoubiquitylation.

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Acknowledgements

The work of P.P.D.F. and S.P. is supported by grants from the Italian Association for Cancer Research (AIRC), Human Science Frontier Programme, International Association for Cancer Research (IARC), The European Community (VI Framework) and the Telethon Foundation. We thank L. Hicke for critically reviewing this manuscript. We apologize to the many colleagues whose work could not be properly acknowledged owing to space limitations.

Author information

Authors and Affiliations

  1. Istituto Europeo di Oncologia, Via Ripamonti 435, Milan, 20141, Italy

    Pier Paolo Di Fiore

  2. Istituto FIRC di Oncologia Molecolare, Milan, 20139, Italy

    Pier Paolo Di Fiore

  3. the University of Milan, Milan, 20122, Italy

    Pier Paolo Di Fiore & Simona Polo

  4. MEMOREC Stoffel GmbH, Stoeckheimer Weg 1, D50829, Koeln, Germany

    Kay Hofmann

Authors
  1. Pier Paolo Di Fiore
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  2. Simona Polo
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  3. Kay Hofmann
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Correspondence to Pier Paolo Di Fiore.

Related links

Related links

DATABASES

InterPro

14-3-3

CUE

forkhead-associated

PTB

UBA

UEV

UIM

SH2

SH3

WW

Swiss-Prot

CIN85

Ent1

Ent2

Eps15

Eps15R

Hrs

Mms2

Nedd4

Ste2

TAB2

TSG101

Tollip

Vps9

FURTHER INFORMATION

European Institute of Oncology

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Di Fiore, P., Polo, S. & Hofmann, K. When ubiquitin meets ubiquitin receptors: a signalling connection. Nat Rev Mol Cell Biol 4, 491–497 (2003). https://doi.org/10.1038/nrm1124

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