Review
Nature Reviews Molecular Cell Biology 4, 295-309 (April 2003) | doi:10.1038/nrm1074
New insights into the roles of agrin
Gabriela Bezakova1 & Markus A. Ruegg1 About the authors
Abstract
The heparan sulphate proteoglycan agrin is expressed as several isoforms in various tissues. Agrin is best known as a crucial organizer of postsynaptic differentiation at the neuromuscular junction, but it has recently also been implicated in the formation of the immunological synapse, the organization of the cytoskeleton and the amelioration of function in diseased muscle. So the activities of agrin might be of broader significance than previously anticipated.
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Author affiliations
- Department of Pharmacology/Neurobiology, Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.
Correspondence to: Markus A. Ruegg1 Email: markus-a.ruegg@unibas.ch
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