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Perspective
Nature Reviews Molecular Cell Biology 4, 971–975 (1 December 2003) | doi:10.1038/nrm1258
Lateral phosphorylation propagation: an aspect of feedback signalling?
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Abstract
Local stimulation with epidermal growth factor can induce lateral propagation of epidermal-growth-factor-receptor phosphorylation at the plasma membrane. We discuss mechanisms of phosphorylation propagation and its possible function. Is it the spatial transmission of a local stimulus or is it an aspect of a feedback-signalling-reaction network that generates a switch response to growth-factor stimulation?
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