Review
Nature Reviews Molecular Cell Biology 4, 915-925 (December 2003) | doi:10.1038/nrm1261
Met, metastasis, motility and more
Carmen Birchmeier1,5, Walter Birchmeier2,5, Ermanno Gherardi3,5 & George F. Vande Woude4,5 About the authors
Abstract
Hepatocyte growth factor/scatter factor and its receptor, the tyrosine kinase Met, arose late in evolution and are unique to vertebrates. In spite of this, Met uses molecules such as Gab1 — homologues of which are present in Caenorhabditis elegans and Drosophila melanogaster — for downstream signalling. Pivotal roles for Met in development and cancer have been established: Met controls cell migration and growth in embryogenesis; it also controls growth, invasion and metastasis in cancer cells; and activating Met mutations predispose to human cancer.
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Author affiliations
- Department of Neuroscience, Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13122 Berlin, Germany.
- Department of Cancer Research, Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Strasse 10, 13122 Berlin, Germany.
- Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, United Kingdom.
- Van Andel Research Institute, 333 Bostwick Avenue North East, Grand Rapids, Michigan 49503, USA.
- The authors contributed equally to this work.
Correspondence to: George F. Vande Woude4,5 Email: george.vandewoude@vai.org
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