Review

Nature Reviews Molecular Cell Biology 4, 938-948 (December 2003) | doi:10.1038/nrm1260

Post-translational modifications regulate microtubule function

Stefan Westermann1 & Klaus Weber2  About the authors

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The alphabeta-tubulin heterodimer, the building block of microtubules, is subject to a large number of post-translational modifications, comparable in diversity to the intensively studied histone modifications. Although these unusual modifications are conserved throughout evolution, their functions have remained almost completely elusive. Recently, however, important advances in the understanding of how tubulin modifications regulate function and organization have been made.

Author affiliations

  1. Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA.
  2. Max Planck Institute for Biophysical Chemistry, Department of Biochemistry, Am Fassberg 11, 37077 Goettingen, Germany.

Correspondence to: Stefan Westermann1 Email: swesterm@uclink.berkeley.edu

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