Review
Nature Reviews Molecular Cell Biology 4, 960-970 (December 2003) | doi:10.1038/nrm1259
Splicing double: insights from the second spliceosome
Abhijit A. Patel1 & Joan A. Steitz1 About the authors
Abstract
Almost 20 years after the discovery of introns and RNA splicing, a second spliceosome was uncovered. Although this new spliceosome is structurally and functionally analogous to the well-characterized major-class splicing apparatus, it mediates the excision of a minor class of evolutionarily conserved introns that have non-canonical consensus sequences. This unanticipated diversity in the splicing machinery is refining both the mechanistic understanding and evolutionary models of RNA splicing.
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Author affiliations
- Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, 295 Congress Avenue, New Haven, Connecticut 06536, USA.
Correspondence to: Joan A. Steitz1 Email: js228@email.med.yale.edu
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