Perspectives
Nature Reviews Molecular Cell Biology 4, 971-975 (December 2003) | doi:10.1038/nrm1258
Opinion: Lateral phosphorylation propagation: an aspect of feedback signalling?
Christian Tischer1 & Philippe I. H. Bastiaens1 About the authors
Top of page
Abstract
Local stimulation with epidermal growth factor can induce lateral propagation of epidermal-growth-factor-receptor phosphorylation at the plasma membrane. We discuss mechanisms of phosphorylation propagation and its possible function. Is it the spatial transmission of a local stimulus or is it an aspect of a feedback-signalling-reaction network that generates a switch response to growth-factor stimulation?
Author affiliations
-
Christian Tischer and Philippe I. H. Bastiens are at the European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
Email: bastiaen@embl-heidelberg.de
|
MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated RESEARCH |
