Review
Nature Reviews Molecular Cell Biology 4, 926-938 (December 2003) | doi:10.1038/nrm1257
Syndecans: proteoglycan regulators of cell-surface microdomains?
John R. Couchman1 About the author
Abstract
Syndecans function as membrane receptors for a bewildering array of ligands through their glycosaminoglycan chains but their precise roles have been hard to pin down. Syndecans have previously been considered as ligand gatherers, working as co-receptors in collaboration with signalling receptors, but their potential to signal independently is now clear. New structural features of syndecan cytoplasmic domains have been described, together with new insights into signalling across the cell membrane that might involve the concentration of ligands in membrane microdomains.
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Author affiliations
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Division of Biomedical Sciences, Faculty of Medicine, Imperial College London, Exhibition Road, London SW7 2AZ, UK.
Email: j.couchman@imperial.ac.uk
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