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Review
Nature Reviews Molecular Cell Biology 4, 855–864 (1 November 2003) | doi:10.1038/nrm1246
Ratchets and clocks: the cell cycle, ubiquitylation and protein turnover
Abstract
Both the cell-cycle and ubiquitin-mediated-proteolysis fields have come of age over the past ten years. One byproduct of the impressive progress in these areas of investigation is the realization that they are intricately related: cell-cycle control is crucially dependent on the ubiquitin-mediated degradation of key regulatory proteins. Very recent advances have allowed an understanding of protein degradation and cell-cycle control at greatly enhanced levels of resolution. Consolidating these advances is likely to provide new insights into the regulatory biology of cell-cycle transitions.
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