Review
Nature Reviews Molecular Cell Biology 4, 833-841 (November 2003) | doi:10.1038/nrm1242
Some assembly required: the development of neuronal synapses
Zheng Li1 & Morgan Sheng1 About the authors
Abstract
Neurons in the brain touch and communicate with each other at specialized contacts called synapses. So, how do these tiny intercellular junctions form during development? The assembly of neuronal synapses proceeds through several stages, and occurs with surprising speed. Recent biochemical, genetic and imaging studies are beginning to disclose the molecular mechanisms that underlie synapse formation, growth and maturation.
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Author affiliations
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The Picower Center for Learning and Memory, RIKEN-Massachusetts Institute of Technology Neuroscience Research Center, Howard Hughes Medical Institute, Massachusetts Institute of Technology, 77 Massachusetts Avenue (E18-215), Cambridge, Massachusetts 02139, USA.
Email: zhengli@mit.edu
Email: msheng@mit.edu
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