Review
Nature Reviews Molecular Cell Biology 4, 767-778 (October 2003) | doi:10.1038/nrm1229
There is a Correction (1 January 2004) associated with this article.
Ras GTPases: integrins' friends or foes?
Kayoko Kinbara1, Lawrence E. Goldfinger1, Malene Hansen2, Fan-Li Chou1 & Mark H. Ginsberg1 About the authors
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Abstract
Integrins are cell-surface receptors that mediate and coordinate cellular responses to the extracellular matrix (ECM). Cellular signalling pathways can regulate cell adhesion by altering the affinity and avidity of integrins for ECM. The Ras family of small G proteins, which includes H-ras, R-ras and Rap, are important elements in cellular signalling pathways that control integrin function.
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Author affiliations
- Department of Cell Biology, The Scripps Research Institute, La Jolla, California 92037, USA.
- Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143, USA.
Correspondence to: Mark H. Ginsberg1 Email: ginsberg@scripps.edu
