Review
Nature Reviews Molecular Cell Biology 4, 13-24 (January 2003) | doi:10.1038/nrm1006
Border-cell migration: the race is on
Denise J. Montell1 About the author
Abstract
The conversion of stationary epithelial cells into migratory, invasive cells is important for normal embryonic development and tumour metastasis. Border-cell migration in the ovary of Drosophila melanogaster has emerged as a simple, genetically tractable model for studying this process. Three distinct signals, which are also upregulated in cancer, control border-cell migration, so identifying further genes that are involved in border-cell migration could provide new insights into tumour invasion.
Author affiliations
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Department of Biological Chemistry, Johns Hopkins School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205-2185, USA.
Email: dmontell@jhmi.edu
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