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Nature Reviews Molecular Cell Biology 3, 702–710 (1 September 2002) | doi:10.1038/nrm914

Signalling through nuclear receptors

Jamshed R. Tata

A century ago, secretions from the pancreas were described as 'hormones', which we now know are secreted from all ductless glands. The development of various technologies has already contributed a great deal — and will undoubtedly offer more — to our understanding of their mode of action.