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Perspective
Nature Reviews Molecular Cell Biology 3, 697–702 (1 September 2002) | doi:10.1038/nrm905
Signalling shortcuts: cell-surface receptors in the nucleus?
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Abstract
Do cell-surface growth-factor receptors and their ligands accumulate in the nucleoplasm under physiological conditions? And, if so, how do they get there and what function do they serve in this location? Recent advances have provided tantalizing hints to the answers to these questions, and hold the key to identifying a new mode of signal transduction.
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