Review
Nature Reviews Molecular Cell Biology 3, 651-662 (September 2002) | doi:10.1038/nrm909
STATs: transcriptional control and biological impact
David E. Levy1 & J. E. Darnell, Jr About the authors
Abstract
Extracellular proteins bound to cell-surface receptors can change nuclear gene expression patterns in minutes, with far-reaching consequences for development, cell growth and homeostasis. The signal transducer and activator of transcription (STAT) proteins are among the most well studied of the latent cytoplasmic signal-dependent transcription-factor pathways. In addition to several roles in normal cell decisions, dysregulation of STAT function contributes to human disease, making the study of these proteins an important topic of current research.
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Author affiliations
- Department of Pathology, New York University School of Medicine, New York, New York 10016, USA.
Correspondence to: J. E. Darnell, Jr Laboratory of Molecular Cell Biology, The Rockefeller University, New York, New York 10021, USA
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