Review
Nature Reviews Molecular Cell Biology 3, 639-650 (September 2002) | doi:10.1038/nrm908
Focus on: SIGNALLING
Seven-transmembrane receptors
Kristen L. Pierce1, Richard T. Premont1 & Robert J. Lefkowitz1 About the authors
Abstract
Seven-transmembrane receptors, which constitute the largest, most ubiquitous and most versatile family of membrane receptors, are also the most common target of therapeutic drugs. Recent findings indicate that the classical models of G-protein coupling and activation of second-messenger-generating enzymes do not fully explain their remarkably diverse biological actions.
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Author affiliations
- The Howard Hughes Medical Institute and the Departments of Medicine and Biochemistry, Box 3821, Duke University Medical Center, Durham, North Carolina, 27710, USA.
Correspondence to: Robert J. Lefkowitz1 Email: Lefko001@receptor-biol.duke.edu
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