Perspectives
Nature Reviews Molecular Cell Biology 3, 697-702 (September 2002) | doi:10.1038/nrm905
Opinion: Signalling shortcuts: cell-surface receptors in the nucleus?
Alan Wells1 & Ulrich Marti2 About the authors
Top of page
Abstract
Do cell-surface growth-factor receptors and their ligands accumulate in the nucleoplasm under physiological conditions? And, if so, how do they get there and what function do they serve in this location? Recent advances have provided tantalizing hints to the answers to these questions, and hold the key to identifying a new mode of signal transduction.
Author affiliations
- Alan Wells is at the Department of Pathology, 713 Scaife, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.
- Ulrich Marti is at the Department of Clinical Chemistry, University Hospital, CH-3010 Berne, Switzerland.
Correspondence to: Alan Wells1 Email: wellsa@msx.upmc.edu
