Review
Nature Reviews Molecular Cell Biology 3, 555-565 (August 2002) | doi:10.1038/nrm878
The protein import motor of mitochondria
Walter Neupert1 & Michael Brunner2 About the authors
Abstract
Proteins that are destined for the matrix of mitochondria are transported into this organelle by two translocases: the TOM complex, which transports proteins across the outer mitochondrial membrane; and the TIM23 complex, which gets them through the inner mitochondrial membrane. Two models have been proposed to explain how this protein-import machinery works — a targeted Brownian ratchet, in which random motion is translated into vectorial motion, or a 'power stroke', which is exerted by a component of the import machinery. Here, we review the data for and against each model.
- View At a Glance
Author affiliations
-
Institut für Physiologische Chemie, Universität München, Butenandtstra
e 5, Gebäude B, D-81377 Munich, Germany. - Biochemie-Zentrum Heidelberg, Im Neuenheimer Feld 328, 69120 Heidelberg, Germany.
Correspondence to: Walter Neupert1 Email: neupert@bio.med.uni-muenchen.de
|
MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated REFERENCE NEWS AND VIEWS RESEARCH |
