Review
Nature Reviews Molecular Cell Biology 3, 475-486 (July 2002) | doi:10.1038/nrm856
Mechanisms and functions of eph and ephrin signalling
Klas Kullander1 & Rüdiger Klein2 About the authors
Abstract
Eph receptors constitute the largest family of tyrosine kinase receptors and, together with their plasma-membrane-bound ephrin ligands, have many important functions during development and adulthood. In contrast with most receptor tyrosine kinases, unidirectional signalling can originate from the ephrin ligands as well as from the Eph receptors. Furthermore, the concept of bidirectional signalling has emerged as an important mechanism by which Ephs and ephrins control the output signal in processes of cell–cell communication.
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Author affiliations
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AstraZeneca Transgenics & Comparative Genomics (ATCG), S-431 83 Mölndal, Sweden.
Email: klas.kullander@astrazeneca.com -
Department of Molecular Neurobiology, Max Planck Institute of Neurobiology, Am Klopferspitz 18A, D-82152 Martinsried, Germany.
Email: rklein@neuro.mpg.de
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