Review
Nature Reviews Molecular Cell Biology 3, 498-508 (July 2002) | doi:10.1038/nrm855
Synaptotagmin: A Ca2+ sensor that triggers exocytosis?
Edwin R. Chapman1 About the author
Abstract
It has been fifty years since the discovery that Ca2+ triggers the rapid exocytosis of neurotransmitters from neurons. One of the proteins that has a crucial role in this secretion event is synaptotagmin I, an abundant constituent of synaptic vesicles that binds Ca2+ ions through two C2 domains. These properties prompted the idea that synaptotagmin I might function as a Ca2+-sensor that triggers neurotransmitter release. So does synaptotagmin trigger exocytosis in a Ca2+-dependent manner, and, if so, how does it operate?
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Author affiliations
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Department of Physiology, University of Wisconsin, Madison, Wisconsin 53706, USA.
Email: chapman@physiology.wisc.edu
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