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Review
Nature Reviews Molecular Cell Biology 3, 317–327 (1 May 2002) | doi:10.1038/nrm805
The MRE11 complex: at the crossroads of DNA repair and checkpoint signalling
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Abstract
The Mre11 complex is a multisubunit nuclease that is composed of Mre11, Rad50 and Nbs1/Xrs2. Mutations in the genes that encode components of this complex result in DNA- damage sensitivity, genomic instability, telomere shortening and aberrant meiosis. The molecular defect that underlies these phenotypes has long been thought to be related to a DNA repair deficiency. However, recent studies have uncovered functions for the Mre11 complex in checkpoint signalling and DNA replication.
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