Review

Nature Reviews Molecular Cell Biology 3, 328-338 (May 2002) | doi:10.1038/nrm806

The subcellular destinations of apc proteins

Mariann Bienz1  About the author

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Adenomatous polyposis coli (APC) is an important tumour suppressor in the human colon, and is conserved in various organisms. Its best understood function is the destabilization of beta-catenin, a key effector of the Wnt signalling pathway. APC proteins are highly motile, and shuttle between several subcellular destinations. These destinations have prompted the discovery of new functions for the APC proteins, and this multitasking of APC might explain why its loss often leads to cancer.

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Author affiliations

  1. MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.Email: mb2@mrc-lmb.cam.ac.uk
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REFERENCE
Signal Transduction Pathways in Development: Wnts and their Receptors
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Mammalian Embryo: Wnt Signalling
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NEWS AND VIEWS
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RESEARCH
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