Review
Nature Reviews Molecular Cell Biology 3, 317-327 (May 2002) | doi:10.1038/nrm805
The MRE11 complex: at the crossroads of DNA repair and checkpoint signalling
Damien D'Amours1 & Stephen P. Jackson1 About the authors
Abstract
The Mre11 complex is a multisubunit nuclease that is composed of Mre11, Rad50 and Nbs1/Xrs2. Mutations in the genes that encode components of this complex result in DNA- damage sensitivity, genomic instability, telomere shortening and aberrant meiosis. The molecular defect that underlies these phenotypes has long been thought to be related to a DNA repair deficiency. However, recent studies have uncovered functions for the Mre11 complex in checkpoint signalling and DNA replication.
Author affiliations
- Wellcome Trust and Cancer Research UK Institute of Cancer and Developmental Biology, and Department of Zoology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK.
Correspondence to: Stephen P. Jackson1 Email: spj13@mole.bio.cam.ac.uk
|
MORE ARTICLES LIKE THIS These links to content published by NPG are automatically generated REFERENCE NEWS AND VIEWS RESEARCH |
