Review
Nature Reviews Molecular Cell Biology 3, 94-103 (February 2002) | doi:10.1038/nrm729
The vacuolar (H+)-ATPases — nature's most versatile proton pumps
Tsuyoshi Nishi1 & Michael Forgac1 About the authors
Abstract
The pH of intracellular compartments in eukaryotic cells is a carefully controlled parameter that affects many cellular processes, including intracellular membrane transport, prohormone processing and transport of neurotransmitters, as well as the entry of many viruses into cells. The transporters responsible for controlling this crucial parameter in many intracellular compartments are the vacuolar (H+)-ATPases (V-ATPases). Recent advances in our understanding of the structure and regulation of the V-ATPases, together with the mapping of human genetic defects to genes that encode V-ATPase subunits, have led to tremendous excitement in this field.
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Author affiliations
- Department of Physiology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, Massachusetts 02111, USA.
Correspondence to: Michael Forgac1 Email: michael.forgac@tufts.edu
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