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Review
Nature Reviews Molecular Cell Biology 3, 919–931 (1 December 2002) | doi:10.1038/nrm974
Sorting out the cellular functions of sorting nexins
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Abstract
Sorting nexins are a diverse group of cellular trafficking proteins that are unified by the presence of a phospholipid-binding motif — the PX domain. The ability of these proteins to bind specific phospholipids, as well as their propensity to form protein–protein complexes, points to a role for these proteins in membrane trafficking and protein sorting. It will be interesting to determine whether the various sorting nexins have specialized or generalized roles in protein trafficking.
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