Review
Nature Reviews Molecular Cell Biology 3, 932-943 (December 2002) | doi:10.1038/nrm977
uPAR: a versatile signalling orchestrator
Francesco Blasi1 & Peter Carmeliet2 About the authors
Abstract
The plasminogen system has been implicated in clot lysis, wound healing, tissue regeneration, cancer and many other processes that affect health and disease. The urokinase receptor uPAR was originally thought to assist the directional invasion of migrating cells, but it is now becoming increasingly evident that this proteinase receptor elicits a plethora of cellular responses that include cellular adhesion, differentiation, proliferation and migration in a non-proteolytic fashion.
Author affiliations
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Department of Molecular Biology and Functional Genomics, DIBIT, Università Vita Salute San Raffaele, Via Olgettina 58, 20132 Milano, Italy.
Email: blasi.francesco@lsr.it -
Center for Transgene Technology and Gene Therapy, Flanders Interuniversity Institute for Biotechnology, KU Leuven, Campus Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium.
Email: peter.carmeliet@med.kuleuven.ac.be
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