Perspectives
Nature Reviews Molecular Cell Biology 3, 964-970 (December 2002) | doi:10.1038/nrm975
Timeline: Protein engineering 20 years on
James A. Brannigan1 & Anthony J. Wilkinson1 About the authors
Abstract
It is 20 years since site-directed mutagenesis was first used to modify the active site of an enzyme of known structure and mechanism. Since then, this method has contributed far-reaching insights into catalysis, specificity, stability and folding of proteins. Engineered proteins are now being used in industry and for the improved treatment of human disease.
Author affiliations
- James A. Brannigan and Anthony J. Wilkinson are at the Structural Biology Laboratory, Department of Chemistry, University of York, York YO10 5YW, UK.
Correspondence to: James A. Brannigan1 Email: jab@ysbl.york.ac.uk
Correspondence to: Anthony J. Wilkinson1 Email: ajw@ysbl.york.ac.uk
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